Fig. 7.
Synaptic input onto oversized Fezf2+ granule cells is altered. (A) Representative mEPSCs recorded from a control cell (Upper) and a Fezf2+ oversized cell (Lower). mEPSC amplitude (B) and frequency (C) are not significantly changed in Fezf2 os cells, but a cumulative distribution (D) shows that interevent intervals are significantly shorter in Fezf2+ os cells (***P < 0.001, K-S test). (E) Decay time constant of mEPSCs is slower in Fezf2+ os cells (**P = 0.0051, t test). (F) mIPSCs recorded from a control cell (Upper) and a Fezf2+ os cell (Lower). Mean mIPSC amplitude is increased (G; *P = 0.017) and mIPSC frequency is decreased in Fezf2+ os cells (H; *P = 0.033). (I) Cumulative histogram showing that interevent intervals are significantly shorter in Fezf2+ os cells (****P < 0.0001, K-S test). (J) Decay time constant of mIPSCs is faster in Fezf2+ os cells (**P = 0.0033, t test) (mEPSC ctrl, n = 19/4 cells/mice; mEPSC Fezf2 os, n = 9/7 cells/mice; mIPSC ctrl, n = 16/4 cells/mice; mIPSC Fezf2 os, n = 6/5 cells/mice).