Fig. 4.

Eradication of commensal enteric bacteria overrides Th17 intestinal inflammation in B7-deficient mice. (A) Percentage of IL-17– or IFN-γ–producing mesenteric lymph node CD4⁺ T cells from WT or B7-deficient mice treated with ampicillin, gentamycin, metronidazole, neomycin, and vancomycin in the drinking water compared with no antibiotic treatment control mice day 12 after initiating sustained Treg ablation. (B) Representative colonic tissue histology after H&E staining and cumulative analysis of inflammation disease score for mice described in A. These data are representative of at least three independent experiments, each with similar results. Error bars indicate mean ± SEM. **P < 0.01; ***P < 0.001.