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. 2014 Jul 7;111(29):10672–10677. doi: 10.1073/pnas.1402336111

Fig. 5.

Fig. 5.

Tregs retained in B7-deficient mice suppress expansion of Th17 CD4+ T cells with commensal specificity. (A) Expansion and CD44 expression among I-Ab:2W1S52–68 tetramer-positive CD4+ T cells day 20 after recolonization with C. albicans-2W1S or nonrecombinant C. albicans in B7-deficient or WT mice. (B) Number of Foxp3+ CD4+ T cells with I-Ab:2W1S52–68 specificity for each group of mice described in A. (C) Helios expression among Foxp3+ Tregs with 2W1S commensal specificity compared with bulk (2W1S−) Tregs day 20 after C. albicans-2W1S recolonization. (D) Number of IL-17– or IFN-γ cytokine–producing mesenteric lymph node CD4+ T cells day 12 after initiating Treg ablation in WT compared with B7-deficient Foxp3DTR mice, each colonized with C. albicans-2W1S. (E) Number of IL-17– or IFN-γ cytokine–producing mesenteric lymph node CD4+ T cells with I-Ab:2W1S52–68 specificity for mice described in D. These data are representative of at least three independent experiments each with similar results. Error bars indicate mean ± SEM. ***P < 0.001; n.s., not significant.