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. 2014 Jun 27;111(29):10416–10421. doi: 10.1073/pnas.1402695111

Fig. 2.

Fig. 2.

SERS study of specific binding of felodipine to Aurora A. (A) SERS spectrum of Aurora A (black) and Aurora A complexed with felodipine (red). (B) SERS spectrum of Aurora B (black) and after treatment with felodipine (red). The change in position of modes and appearance of new modes are indicated by blue arrows in A and amide I bands are highlighted in Insets. (C) Mode of attachment of Aurora A to a silver nanoparticle and (D) change in orientation of Aurora A on the silver nanoparticle surface on complexation with felodipine. The N-terminal β-sheet–rich domain and the C-terminal α-helix–rich domains are highlighted in blue and green, respectively. The bound felodipine in D is highlighted in red.