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Loss of FGF signaling results in the activation of astrocytes in the cortex. (A) The intermediate neurofilament protein GFAP (green) is increased in the neocortical gray matter (ctx) of the LOF mutant 4 wk after TM treatment. (Lower) Higher magnifications of boxed areas. Hoechst (blue) is used as a counterstain. (Scale bars: Upper, 150 μm; Lower, 50 μm.). (B) Vimentin and nestin (red) are also increased in the LOF-mutant neocortex and colabel with GFAP (green). (Scale bar: 20 μm.)
