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Loss of KIF2C induces autophagy. (A) LC3-II was immunoblotted in equal amounts of lysates from HBEC3KT and HBEC3KTRL53. (B) Ras was depleted from HBEC3KTRL53 with siRNA. Cells were then treated for 3 d with 100 nM PD0325901, followed by immunoblotting of lysates as indicated. (C) KIF2C was depleted with siRNA from HBEC3KTRL53. Cells were starved for 12 h in EBSS or treated with 10 nM Baflomycin A and immunoblotted with antibodies to p62. ERK1/2 was used as the loading control.
