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. 2014 Jul 9;111(29):10684–10689. doi: 10.1073/pnas.1411026111

Fig. 6.

Fig. 6.

p53 acts cooperatively with SIRT6 to regulate murine blood glucose levels. Glucose levels based on pyruvate tolerance tests on C57BL/6J mice (A) or Sirt6 shRNA-pretreated C57BL/6J mice (B) that were injected with an empty plasmid or a recombinant adenovirus plasmid expressing p53 (Ad-WT-p53) after 22 h of fasting. Twenty-four C57BL/6J mice were separated into four groups, with six mice per group. Data are reported as the mean ± SD with *P < 0.05. Glucose levels based on pyruvate tolerance tests on control C57BL/6J mice (C) or conditional liver Sirt6-knockout mice (D) in response to the injection of Ad-GFP or Ad-WT-p53. Twenty-four mice were separated into four groups, with six mice per group. Data are shown as the mean ± SD with *P < 0.05. (E) A hypothetic model showing how p53 coordinates with SIRT6 to regulate gluconeogenesis.