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. 2014 Jul 7;111(29):10396–10397. doi: 10.1073/pnas.1410104111

Fig. 1.

Fig. 1.

(A) Schematic of the original model of the MPTP. The MPTP was proposed to be one contiguous pore composed of VDAC and ANT regulated by CypD, which formed at contact sites between the inner and outer membranes. (B) Schematic of the new model of the MPTP consisting of Bax/Bak on the outer mitochondrial membrane to impart a level of necessary permeability and the F1FO ATP synthase on the inner mitochondrial membrane regulated by CypD in the matrix as the component that responds to stimuli to initiate opening, efflux of Ca2+, loss of membrane potential, and mitochondrial swelling.