Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jul 30;8:223. doi: 10.3389/fnins.2014.00223

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Castellazzi, Palesi, Casali, Vitali, Sinforiani, Wheeler-Kingshott and D'Angelo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Comparison of structural and functional changes in AD and MCI. (A,B) VBM analysis. AD subjects compared to HC (A) show large areas of GM atrophy (orange) in bilateral mesial-temporal network. MCI subjects compared to HC (B) show sparse areas of GM atrophy (orange) in left and right hippocampus, left amygdala, parahippocampal gyrus, precuneus and superior temporal gyrus. AD show more extended areas of atrophy than MCI. (C,D) FC analysis. Both AD and MCI compared to HC show large clusters of FC reductions (blue) mainly localized in the prefrontal areas involving VAN, DMN, DAN, FCN, SN, and SMN, with more extended areas of FC reductions in AD than MCI. (E,F) VBM/FC matching. Matching VBM and FC maps of FC reduction for AD compared to HC and MCI compared to HC. The overlapping between atrophy and FC changes (red clusters) is very limited.