Table 2.
Antithrombotic therapy, follow-up duration, and long-term outcomes of acute childhood-onset AIS.
| Childhood-onset AIS (n=61) | |
|---|---|
| Antithrombotic (AT) therapy | |
| Acute thrombolysis | |
| Systemic | 0% (0) |
| Intra-arterial | 2% (2) |
| Acute AT (0 – 7 d post-diagnosis) | |
| Anti-platelet | 42% (25/60) |
| Anticoagulant | 40% (24/60) |
| Both | 15% (9/60) |
| None | 3% (2/60) |
| Subacute AT (>7 d – < 3 m post-diagnosis) | |
| Anti-platelet | 40% (24/60) |
| Anticoagulant | 43% (26/60) |
| Both | 13% (8/60) |
| None | 3% (2/60) |
| Early chronic AT (3 m – 1 y post-diagnosis) | |
| Anti-platelet | 62% (37/60) |
| Anticoagulant | 23% (14/60) |
| Both | 8% (5/60) |
| None | 7% (4/60) |
| Late chronic AT (> 1 y post-diagnosis) | |
| Anti-platelet | 72% (42/58) |
| Anticoagulant | 7% (4/58) |
| Both | 9% (5/58) |
| None | 12% (7/58) |
| Surgical intervention1 | 26% (16/61) |
| Median follow-up duration | 25 m; range: 2–134 m |
| Cumulative probability of recurrent AIS at 1 y | 6% (3/53) |
| Mortality | 2% (1/61) |
| Major bleeding episodes on therapy2 | 3% (2/61) |
| Prevalence of neuromotor deficit at 1 y | 80% (44/55) |
| Median PSOM3 (scored at or beyond 1 y) | 1.5 (0–7) |
Abbreviations: AIS=arterial ischemic stroke, PSOM=Pediatric Stroke Outcome Measurement Number of subjects affected is given in parentheses.
1
Includes direct bypass (n=1), indirect bypass (n=5), craniotomy (n=3), closure of shunting cardiac lesion (n=3), stent placement (n=1), coil placement (n=1), and pseudoaneurysm repair via excision and direct anastomosis (n=1).
2
For definitions, see Methods.
3
n=41