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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2014 May;73(5):378–386. doi: 10.1097/NEN.0000000000000068

Figure 2.

Figure 2

Recognition of damage-associated molecular patterns (DAMPs) by toll-like receptors (TLR)s. DAMPs are endogenous TLR ligands that are released after injury. They can have extracellular, intracellular or nuclear origin. Once released, DAMPs can bind and activate their cognate TLR. Abbreviations: HMGB1, high mobility group box 1; HSPs, heat shock proteins; Prx, peroxiredoxin protein.