Figure 1.

Genomic organization of long noncoding RNAs (lncRNAs). Schematic diagram illustrating the complexity of the network of the long noncoding transcript (oblique line box) that is associated with a representative gene (hollow box). The orientations of transcription indicated by arrows. Sense, The lncRNA sequence overlaps with the sense strand of a protein-coding gene; Antisense, The lncRNA sequence overlaps with the antisense strand of a protein-coding gene; Bidirectional, The lncRNA sequence is located on the opposite strand from a protein-coding gene whose transcription is initiated <1,000 base pairs away; Intronic, The lncRNA sequence is derived entirely from within an intron of another transcript. This may be either a true independent transcript or a product of pre- mRNA processing; Intergenic, The lncRNA sequence is not located near any other protein-coding loci.