Table 4.
Comparison of mathematical modeling approaches to estimate infant 1 lactational dose in 2 humans (Adapted from ICF International (2013))
| Modeling approach | Infant nursing duration (months) |
Infant lactational dose (ng HCB/kg bw-day) corresponding to an average daily maternal exposure of 1 ng HCB/kg bw-day* |
|---|---|---|
| Multi-compartment model (Verner et al., 2009) |
1 | 26 |
| 12 | 21 | |
| Two-compartment model (Verner et al., 2013) |
1 | 34 |
| 12 | 32 | |
| Toxicokinetic model (ICF International, 2013) |
1 | 23 |
| 12 | 17 | |
| U.S. EPA model (U.S. EPA, 1998) |
1 | 29 |
| 12 | 23 | |
| No-elimination model (Rogan and Ragan, 1994) |
1 | 97 |
| 12 | 77 |
*
Infant lactational dose is averaged over the nursing duration.