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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Crit Rev Toxicol. 2014 Aug;44(7):600–617. doi: 10.3109/10408444.2014.926306
BB(t) = the time-dependent total body burden of the maternal animal (mg/kg);
fam = the fraction of ingested chemical absorbed by the maternal animal
(dimensionless);
DImat(t) = the time-dependent dose administered to the maternal animal
(mg/kg bw-day); and
kelim = the first order elimination rate (days−1) = ln(2)/half-life (days).