Table 1.

Hot plate test reaction times (in sec) for 5 days in dexmedetomidine-administered rats

Day	Baseline	5 min		10 min		20 min		30 min		40 min		60 min		90 min
	median (min-max)	median (min-max)	p	median (min-max)	p	median (min-max)	p	median (min-max)	p	median (min-max)	p	median (min-max)	p	median (min-max)	p
1	7.45 (6.25–8.60)	14.00 (6.00–16.40)	0.017	13.95 (9.90–20.00)	0.012	12.90 (10.70–14.50)	0.012	8.95 (5.10–11.50)	0.141	7.00 (5.00–9.70)	0.324	6.80 (5.20–7.90)	0.107	6.65 (5.00–7.80)	0.035
2	8.87 (6.00–10.20)	16.45 (11.00–20.70)	0.012	16.50 (14.10–20.20)	0.012	15.80 (13.60–19.80)	0.012	9.30 (7.80–14.00)	0.030	8.10 (6.00–13.10)	0.553	8.15 (6.30–9.00)	0.025	8.25 (6.70–9.80)	0.123
3	7.22 (6.30–8.40)	15.50 (13.20–22.00)	0.012	15.55 (13.00–20.00)	0.012	14.70 (12.50–17.00)	0.012	8.50 (6.80–11.00)	0.017	6.95 (6.00–8.30)	0.017	7.15 (6.20–7.90)	0.046	6.85 (6.00–7.00)	0.036
4	7.77 (7.00–8.25)	18.05 (16.60–24.00)	0.012	16.95 (14.80–22.00)	0.012	15.90 (14.90–19.90)	0.012	11.35 (9.30–13.00)	0.012	7.75 (7.20–9.10)	0.327	7.70 (7.00–9.00)	0.575	7.45 (6.90–8.00)	0.205
5	7.90 (6.25–8.10)	17.75 (16.00–21.00)	0.012	17.35 (15.30–24.00)	0.012	16.75 (15.00–18.50)	0.012	11.10 (10.00–12.00)	0.012	7.90 (7.00–8.70)	0.233	7.85 (6.50–8.30)	0.497	7.45 (6.10–8.00)	0.011