Table 2.

Tail-flick test reaction times (in sec) for 5 days in dexmedetomidine-administered rats

Day	Baseline	5 min		10 min		20 min		30 min		40 min		60 min		90 min
	median (min-max)	median (min-max)	p	median (min-max)	p	median (min-max)	p	median (min-max)	p	median (min max)	p	median (min-max)	p	median (min-max)	p
1	5.22 (4.40–5.50)	9.20 (8.30–10.50)	0.012	9.85 (7.90–13.20)	0.012	8.40 (7.00–9.70)	0.012	6.25 (5.00–7.40)	0.036	5.90 (5.00–7.00)	0.030	5.15 (4.00–6.20)	0.888	4.65 (4.00–6.00)	0.292
2	3.65 (2.75–5.15)	6.45 (5.80–10.30)	0.012	7.20 (6.00–10.90)	0.012	7.05 (5.70–9.70)	0.011	4.75 (4.00–6.70)	0.012	4.00 (3.00–5.00)	0.499	3.70 (3.00–5.10)	0.361	3.55 (3.00–4.90)	0.833
3	3.07 (2.85–3.90)	6.95 (6.20–7.20)	0.012	6.35 (6.20–8.00)	0.011	6.45 (6.00–7.70)	0.012	3.60 (3.00–5.10)	0.043	3.15 (3.00–4.00)	0.400	3.20 (2.50–3.50)	0.574	2.85 (2.50–3.50)	0.093
4	3.47 (3.10–4.10)	7.10 (6.50–8.10)	0.012	7.20 (6.70–8.00)	0.012	7.20 (6.40–8.20)	0.012	5.15 (4.60–6.70)	0.012	3.85 (3.60–5.00)	0.012	3.25 (3.00–3.70)	0.068	3.25 (3.10–3.70)	0.075
5	3.52 (3.24–3.75)	7.65 (7.20–7.80)	0.012	7.45 (7.30–7.90)	0.012	7.25 (6.90–7.50)	0.012	4.90 (4.20–5.20)	0.012	4.10 (4.00–4.90)	0.012	3.75 (3.00–4.30)	0.122	3.45 (3.10–4.20)	0.574