Table 1.

Potential role of NGF and BDNF in the pathogenesis of a selected list of diseases

Neurodegenerative diseases Alzheimer’s disease, Huntington’s disease, Parkinson’s disease Human immunodeficiency virus-associated dementia Diabetic neuropathy

Psychiatric diseases Depression, Schizophrenia Eating disorders   Anorexia nervosa   Bulimia nervosa

Ocular diseases Glaucoma, Retinitis pigmentosa, Diabetic retinopathy Corneal diseases   Peripheral ulcerative keratopathy   Dry eye

Cardiometabolic diseases Atherosclerosis, Hypertension, Obesity, Type 2 diabetes mellitus, Metabolic syndrome

Heart failure, Myocardial infarction Sudden cardiac death in diabetes mellitus (silent myocardial ischemia in diabetes mellitus)

Skin diseases Diabetic wounds, Pressure ulcers, Chronic vasculitic ulcers

Malignant diseases Prostate cancer, Breast cancer, Melanoma

Urinary system diseases Overactive bladder syndrome, Benign prostatic hyperplasia

Chronic pain-associated disorders Osteoarthritis, Low back or spinal injuries, Cancer Urological chronic pelvic pain syndromes