Figure 3.

Afferent arteriolar responses to S1P receptor activation. (A) Afferent arteriolar responses to increasing concentrations of FTY720 (a S1P receptor agonist except S1P2 receptors; squares), FTY720-phosphate (the active form of FTY720; diamonds), and SEW2871 (a selective S1P1 receptor agonist; triangles) compared with the vasoconstriction induced by S1P (circles; data from Figure 1). Data represent the actual diameters from each group. (B) The same data normalized as the percentage of control diameter for each group. Values are expressed as the mean±SEM. *P<0.05 versus the baseline diameter in the same group. n=6–7 in each group.