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. 2014 Feb 27;25(8):1774–1785. doi: 10.1681/ASN.2013060656

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Copyright © 2014 by the American Society of Nephrology

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Figure 5. — Effect of L-type calcium channel blockade on S1P-mediated afferent arteriolar vasoconstriction. (A) Effect of superfusion with diltiazem (10 μM) on S1P (0.1 μM) mediated afferent arteriolar vasoconstriction. (B) Effect of superfusion with nifedipine at 1, 3, or 5 μM, respectively, on S1P (0.1 μM) mediated afferent arteriolar vasoconstriction. Data are expressed as the percent reduction in diameter induced by S1P for each group. Values are expressed as the mean±SEM. *P<0.05 indicates a significant reduction in diameter by S1P versus control; ^†P<0.05 versus vasoconstriction with superfusion of S1P alone. n=6 in each group.