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. 2014 Feb 27;25(8):1774–1785. doi: 10.1681/ASN.2013060656

Figure 6.

Figure 6.

Effect of intravenous injections of exogenous S1P on RBF in anesthetized rats in vivo. RBF is assessed in anesthetized rats in vivo by bolus injections of S1P (circles; n=6) or methanol as vehicle control (squares; n=3) via the femoral vein at least at 5-minute intervals. Baseline RBF is similar between S1P and vehicle control groups (9.7±0.7 versus 9.5±1.3 ml/min g kidney weight). (A) Dose-dependent reduction in RBF in responses to bolus injections of S1P (circles, n=6) compared with vehicle control rats (squares, n=3). Data are expressed as the mean±SEM. *P<0.05 versus the baseline RBF before a bolus of S1P injection. (B) Original recording from a representative rat showing rapid and transient reductions in RBF (bottom traces) in response to increasing bolus injections of S1P without significant changes in BP (top traces). Vertical dash lines indicate S1P injection. Bar=5-second period. BW, body weight.