Figure 5.

Treatment with specific periostin AS ODNs protects against the development of L-NAME–induced renal disease. (A) Representative renal sections stained by Masson’s Trichromic showing that rats treated with L-NAME and periostin AS display less fibrosis and tubular dilation compared with vehicle- or Scr-treated groups. (B) Quantifications of vascular hypertrophy, glomerulosclerosis, perivascular fibrosis, and tubular dilation confirm this protection. Data are mean±SEM. Six rats per treatment were used. Veh, vehicle. *P<0.05; ***P<0.001.