Table 5.
Candidate gene analysis for uromodulin indexed to creatinine in the overall population
| Gene Name | Chr | SNPs Found in Gene (n) | LD Blocks in Gene at R2=0.2 (n) | Gene-Specific Threshold | SNPs in Gene with P Value Below Threshold (n) | SNP ID with Lowest P Value in Gene | Lowest P Value in Gene | FDR | eGFR Cr P Value in CKDGen | Gene Category |
|---|---|---|---|---|---|---|---|---|---|---|
| KCNJ1(ROMK)a | 11 | 40 | 5 | 0.010 | 1 | rs2855800 | 0.001 | 0.1914 | 0.023 | Ion transport |
| CAB39a | 2 | 43 | 6 | 0.008 | 1 | rs2438298 | 0.002 | 0.2962 | 0.065 | Regulator, ion transport |
| SORL1a | 11 | 120 | 9 | 0.006 | 3 | rs1532763 | 0.004 | 0.4381 | 0.29 | Regulator, ion transport |
| HNF1B | 17 | 36 | 9 | 0.006 | 0 | rs4239217 | 0.01 | 0.7178 | 0.38 | Transcription factor |
| REN | 1 | 21 | 6 | 0.008 | 0 | rs11571093 | 0.02 | >0.75 | 0.64 | Regulator, ion transport |
| STK39 | 2 | 362 | 15 | 0.003 | 0 | rs2203703 | 0.02 | >0.75 | 0.19 | Regulator, ion transport |
| CLDN14 | 21 | 165 | 12 | 0.004 | 0 | rs4816538 | 0.03 | >0.75 | 0.9 | Paracellular, ion transport |
| CLDN16 | 3 | 56 | 6 | 0.008 | 0 | rs17445530 | 0.03 | >0.75 | 0.69 | Paracellular, ion transport |
| CNNM2 | 10 | 137 | 6 | 0.008 | 0 | rs12769080 | 0.06 | >0.75 | 0.1 | Ion transport |
| SLC9A3 | 5 | 27 | 7 | 0.007 | 0 | rs1035908 | 0.07 | >0.75 | 0.94 | Ion transport |
| CLCNKB | 1 | 27 | 5 | 0.010 | 0 | rs2007471 | 0.07 | >0.75 | 0.21 | Ion transport |
| SLC9A4 | 2 | 168 | 7 | 0.007 | 0 | rs17027258 | 0.07 | >0.75 | 0.45 | Ion transport |
| NFAT5 | 16 | 75 | 6 | 0.008 | 0 | rs1064825 | 0.08 | >0.75 | 0.017 | Transcription factor |
| SLC9A2 | 2 | 81 | 12 | 0.004 | 0 | rs13011360 | 0.11 | >0.75 | 0.49 | Ion transport |
| AGT | 1 | 48 | 5 | 0.010 | 0 | rs3789664 | 0.11 | >0.75 | 0.52 | Regulator, ion transport |
| WNK1 | 12 | 104 | 8 | 0.006 | 0 | rs7137188 | 0.13 | >0.75 | 0.15 | Regulator, ion transport |
| CLCNKA | 1 | 34 | 3 | 0.017 | 0 | rs1889785 | 0.15 | >0.75 | 0.34 | Ion transport |
| CASR | 3 | 75 | 8 | 0.006 | 0 | rs3804593 | 0.15 | >0.75 | 0.65 | Regulator, ion transport |
| OXSR1 | 3 | 19 | 5 | 0.010 | 0 | rs4955408 | 0.22 | >0.75 | 0.75 | Regulator, ion transport |
| SLC12A1 | 15 | 44 | 1 | 0.050 | 0 | rs1843144 | 0.22 | >0.75 | 0.38 | Ion transport |
| CLDN19 | 1 | 8 | 3 | 0.017 | 0 | rs7548008 | 0.31 | >0.75 | 0.73 | Paracellular, ion transport |
| BSND | 1 | 20 | 2 | 0.025 | 0 | rs12134118 | 0.31 | >0.75 | 0.55 | Ion transport |
| WNK4 | 17 | 1 | 1 | 0.050 | 0 | rs873084 | 0.34 | >0.75 | 0.2 | Regulator, ion transport |
| HIF1A | 14 | 28 | 2 | 0.025 | 0 | rs7143164 | 0.43 | >0.75 | 0.19 | Transcription factor |
The table is sorted after lowest P value in the gene. Significance was defined as P value lower than a gene-specific threshold, calculated as 0.05 divided by the number of found LD blocks at R2=0.2 in that gene. Chr, chromosome; FDR, false discovery rate; Cr, creatinine.
a
Three loci with at least one SNP with a P value below the threshold in the gene. The FDR values <0.75 are provided as an alternative threshold (see the Concise Methods).