. Author manuscript; available in PMC: 2014 Nov 1.

Published in final edited form as: Clin Pharmacol Ther. 2013 Jul 26;94(5):570–573. doi: 10.1038/clpt.2013.153

Table 1.

Profiled metabolites that are altered upon aspirin exposure

Pathway	Metabolite
Aspirin and xenobiotic metabolism	↑ 2,183% Salicylic acid^a	↑ 7% Glucuronic acid^a	↓ 7% 2-Hydroxybutanoic acid^a
Aspirin and xenobiotic metabolism	↑ 160% 2-Hydroxyhippuric acid^a	↑ 26% Benzylalcohol^a	—
Purine pathway	↑ 77% Inosine^a	↓ 5% Hypoxanthine^a	—
Purine pathway	↑ 8% Guanosine^a	↓ 9% Xanthine^a	—
Fatty acids	↓ 28% Oleic acid^a	↓ 20% Azelaic acid^a	↓ 15% Lauric acid^a
	↓ 31% Palmitoleic acid^a	↑ 11% Threonic acid^a	↓ 32% Elaidic acid^a
	↓ 15% Myristic acid^a	↓ 9% Isolinoleic acid^a	↓ 14% Capric acid^a
	↓ 19% Linoleic acid^a	↓ 10% Palmitic acid^a	↓ 9% Methylhexadecanoic acid^a
Glycerol metabolism	↓ 14% 1-Monoolein^a	↓ 13% Glycerol^a	↑ 14% Glycerol-3-galactoside^a
Amino acids and related metabolites	↓ 40% Glycylglycine^c	↓ 9% Phenylalanine^b	↓ 5% γ-Aminobutyric acid^c
	↓ 24% L-Aspartic acid^b	↓ 9% Ethanolamine^c	↓ 5% Serine^b
	↑ 19% O-phosphoethanolamine^c	↑ 8% Indole-3-acetate^a	↓ 5% Ornithine^c
	↑ 16% Methionine^a	↑ 7% Serotonin^c	↓ 4% L-Lysine^c
	↑ 12% Phenylacetic acid^a	↓ 6% Taurine^c	↓ 2% L-Histidine^c
	↑ 11% Hydrocinnamic acid^a	↓ 6% Leucine^b	—
	↓ 10% L-Glutamic acid^b	↓ 5% L-Valine^b	—
Carbohydrates and carbohydrate conjugates	↑ 5% Glucose^a	↑ 7% Threitol^a	↓ 10% Xylulose^a
Carbohydrates and carbohydrate conjugates	↓ 13% 3-Hydroxybutanoic acid^a	—	—
Other	↑ 7% Conduritol-β-epoxide^a	↑ 9% Maleimide^a	—

↑ = Metabolite increased after aspirin exposure; ↓ = metabolite decreased after aspirin exposure. Median percentage change in metabolite levels is provided. For metabolites measured by both GC-MS and LC-MS, percentage change from LC-MS is provided.

GC-MS, gas chromatography-mass spectrometry; LC-MS, liquid chromatography-mass spectrometry.

Measured by GC-MS.

Measured by GC-MS and LC-MS.

Measured by LC-MS