(A) Blood glucose levels of C57BL/6 mice before and 6 h after treatment with water (VEH, n= 7 mice), Metformin® (MET, n= 5), SPI (n= 7), 5011-Nutrasorb (n= 7 mice per dose), or PMI-5011 (n= 6). The second row of numbers represent the dose of DMC-2 (μg/kg) delivered in the indicated doses of test material (mg/kg). Each bar represents data mean ± SD. Between group comparisons before treatment (T= 0 h) indicated that all groups had similar blood glucose (ANOVA, p= 0.26). Between group comparisons after treatment (T= 6 h) indicated significant differences (ANOVA, p= 1.0 ×10−5, followed by unequal N HSD post hoc test). Absence of letters (a, b, c) or same letters indicates no difference while different letter subscripts indicate significant differences.