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. 2014 Jul 30;9(7):e102839. doi: 10.1371/journal.pone.0102839

Figure 1. Scheme of the idiotypic network and specificity of the AIM2 response.

Figure 1

a) The idiotypic network. An antigen, Ag, is recognized by its antibody Ab1. The Ab1 becomes itself an antigen eliciting the production of anti-antibodies Ab2. This response can be divided into: i) an antigen-non inhibitable group (Ab2α), ii) an antigen-inhibitable group bringing an “internal image” of the antigen (Ab2β), and iii) an antigen-inhibitable group due to steric hindrance with the antigen binding-site (Ab2γ). b) Specificity of AIM2 response. Immunoreactivity of phage expressed AIM2 scFv was tested by ELISA against MB2.8 (used for selection) and 3 others scFv-Fc. MB3.7 is a celiac-derived anti-TG2 antibody while MB6.2 and MBV5B2 are control antibodies using the VH5 gene for VH Chain.