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Time course of BBB opening induced by PDT or ETXp-PCI. Fischer rats (n = 4 per group) received 1 mg kg−1 AlPcS2a (i.p.) and were irradiated (1 J; 10 mW) 48 h later. The PCI group received an i.p. injection (20 μg kg−1) of ETXp 1 h prior to light irradiation. T1-weighted images were acquired 15 min after i.p. Gd contrast administration [20]. (Reprinted with permission.)
