Figure 3.
(online color at: www.biophotonics-journal.org) Mean contrast volume measured from MRI scans performed 24 h post-PDT using a fluence rate of 10 mW. ALA (125 mg kg−1 i.p.) was administered 4–5 h prior to light delivery. A significant light dose response was apparent with increasing light fluence resulting in increased contrast. A fluence of 26 J, in the absence of ALA (light-only control), resulted in minimal contrast enhancement suggesting an intact BBB [19]. (Reprinted with permission.)