Table 1. Demographics of Patients with Brugada Syndrome (BrS).
| Probands with BrS | Probands with BrS and CCD | |||||
|---|---|---|---|---|---|---|
| Overall | SCN10A+ | SCN10A- | Overall | SCN10A+ | SCN10A- | |
| Patient Demographics | ||||||
| Number of probands | 150 | 25 (Yield 16.67%) | 125 | 36 | 12 (Yield 33.33%) | 24 |
| Family history | 29 (19.33%) | 4 (16.00%) | 25 (20.00%) | 8 (22.22 %) | 3 (25.00%) | 5 (20.83%) |
| Age for diagnosis | 44.48±16.10 | 42.50±13.56 | 44.83±16.61 | 44.75±19.92 | 43.25±15.15 | 45.50±22.18 |
| Male | 101 (67.33%) | 20 (80.00%) | 81 (64.80%) | 27 (75.00%) | 9 (75.00%) | 18 (75.00%) |
| Female | 49 (32.67%) | 5 (20.00%) | 44 (35.20 %) | 9 (25.00%) | 3 (25.00%) | 6 (25.00 %) |
| with CCD | 36 (24.00%) | 12 (48.00%) | 24 (19.20%) | 36 (100.00%) | 12 (100.00%) | 24 (100.00%) |
| ER† | 24 (16.00%) | 8 (32.00%) | 16 (12.80%) | 8 (22.22%) | 3 (25.00%) | 5 (20.83%) |
| bradycardia | 24 (16.00%) | 5 (20.00%) | 19 (15.20%) | 10 (27.78%) | 3 (25.00%) | 7 (29.17%) |
| VT/VF | 33 (22.00%) | 12 (48.00%) | 21 (16.80%) | 12 (33.33%) | 7 (58.33%) | 5 (20.83%) |
| AF | 13 (8.67%) | 2 (8.00%) | 11 (8.80%) | 1 (2.78%) | 0 (0.00%) | 1 (4.17%) |
| Symptom | ||||||
| Asymptomatic | 34 (22.67%) | 1 (4.00%) | 33 (26.40%) | 9 (25.00%) | 1 (8.33%) | 8 (33.33%) |
| Syncope | 39 (26.00%) | 10 (40.00%) | 29 (23.20%) | 10 (27.78%) | 4 (33.33%) | 6 (25.00%) |
| SCD | 20 (13.33%) | 6 (24.00%) | 14 (11.20%) | 3 (16.67%) | 3 (25.00%) | 3 (12.50%) |
| chest pain | 11 (7.33%) | 5 (20.00%) | 6 (4.80%) | 3 (8.33%) | 3 (25.00%) | 0 (0.00%) |
| other symptoms‡ | 54 (36.00%) | 12 (48.00%) | 42 (33.60%) | 11 (33.33%) | 4 (33.33%) | 8 (33.33%) |
| Electrocardiograms | ||||||
| HR (bpm) | 73.82±16.58 | 72.58±16.35 | 74.10±16.69 | 68.07±17.77 | 72.00±21.39 | 65.11±15.31 |
| PR (ms) | 175.97 ± 38.23 | 193.44±31.79* | 171.47±38.42 | 218.29±34.59 | 217.42±24.20 | 218.77±39.66 |
| QRS (ms) | 98.84±17.82 | 105.72±18.85* | 97.26±17.28 | 103.47±19.34 | 107.67±24.01 | 101.38±16.72 |
| QT (ms) | 378.94±42.43 | 384.44±38.67 | 377.70±43.30 | 398.28±44.45 | 388.67±48.18 | 403.08±42.71 |
| QTc (ms) | 414.40±36.22 | 416.05±37.42 | 414.04±36.11 | 416.29±42.24 | 420.40±49.82 | 414.23±38.92 |
*
P<0.05 compared between SCN10A+ and SCN10A-groups.
†
Early repolarization (ER) pattern other than V1-V3
‡
Other symptoms include palpitation, dizziness, sleep apnea, coma, et al.
AF: atrial fibrillation; CCD: cardiac conduction disease; HR: heart rate; SCD: sudden cardiac death; VT/VF: ventricular tachycardia/ventricular fibrillation.