Table 4.

Side Effect Risk Profiles of Common Second-Generation Antipsychotic Medications Used in Children and Adolescents^a

Second-Generation Antipsychotics (trade name)	Anticholinergic	Diabetes	Hyperlipidemia	Hyperprolactinemia	Hypotension	Sedation	Tardive Dyskinesia	Weight Gain
Aripiprazole (Abilify)	0	+	+	0	+	+	+	+
Asenapine (Saphris)	0	+	+	+	0	+	+	+
Clozapine (Clozaril)	+++	+++	++/+++	0	+++	+++	0	+++
Iloperidone (Fanapt)	0	+	+	+	+	+	+	+
Lurasidone (Latuda)	0	+	+	+	0	+	+	+
Olanzapine (Zyprexa)	++	+++	++/+++	+/++	+	+/++	+	+++
Paliperidone (Invega)	0	+	+/++	++	+	+	+	++
Quetiapine (Seroquel)	0/+	++	+/++	0	++	++	0	++
Risperidone (Risperdal)	0	+	+/++	++	++	+	+	++
Ziprasidone (Geodon)	0	+	+	0	+	+	+	+

^aBased on Celano et al⁸⁰ and Correll et al.⁸¹

Symbols: 0 = low risk, + = mild risk, ++ = moderate risk, +++ = high risk.