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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Nat Genet. 2014 Jun 22;46(8):837–843. doi: 10.1038/ng.3013

Figure 4. TP53 mutations can be used to diagnose Barrett’s esophagus with prevalent high-grade dysplasia on the Cytosponge™.

Figure 4

A. The allele fraction of TP53 mutations identified in Cytosponge™ samples is shown for the three patients groups: no Barrett’s esophagus (n=23), Barrett’s esophagus with no dysplasia (n=44) and Barrett’s esophagus with high grade dysplasia (HGD) (n=22). B. The positions of the TP53 mutations identified on the Cytosponge™ samples are shown above the gene diagram compared with those found in the EAC and Barrett’s esophagus HGD biopsy cohorts. The dotted line on the gene outline denotes the two small areas not covered by the multiplex PCR assay (amino acids 1-27 and 361-393). TA, transcription activation domain; OD, oligomerization domain.