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Localized Gβγ inhibition directs PIP3 gradients and lamellipodia. (A) Light-triggered recruitment of CRY2-mCh-GRK2ct to the plasma membrane allows for spatially confined inhibition of βγ signaling. (B) Live-cell imaging of a RAW cell expressing CRY2-mCh-GRK2ct, CIBN-CaaX, PH(Akt)-Venus, and CXCR4. (C) The t-stack corresponding to the data in B. Localization of the GRKct construct generates reversible lamellipodia and PIP3 responses.
