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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1979 Sep;76(9):4632–4635. doi: 10.1073/pnas.76.9.4632

Nicotinic acetylcholine receptor: evidence for a functionally distinct receptor on human lymphocytes.

D P Richman, B G Arnason
PMCID: PMC411633  PMID: 291991

Abstract

The presence of three distinct cholinergic receptors on human lymphocytes was suggested by the effects of carbamoylcholine on lymphocyte proliferation in vitro. The cells responded to both 0.1 nM and 1 microM carbamoylcholine by increased proliferation which was blocked by the muscarinic antagonist atropine. This effect occurred in both mitogen-stimulated cells (maximum effect at 24 hr) and nonstimulated cells (maximum effect at 72 hr). In contrast, 1--10 nM carbamoylcholine produced diminished in vitro proliferation, an effect which was blocked by the nicotinic antagonists alpha-bungarotoxin and d-tubocurarine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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