Figure 2A. H2O2 generation (closed symbols) and O2
uptake (open symbols) monitored with an Apollo 4000 Radical Ion Analyzer in Sf9 microsomes
from baculovirus expressed hFMO1 (diamonds), hFMO2.1(triangles), hFMO3 (squares) with ETU
substrate (50 μM), and hFMO2.1 without substrate (circles) at pH 7.4,
37°C. Substrate was added after a 5 minute pre-incubation with 1 mM NADPH.
Figure 2B. H2O2 yield as a percent of O2 consumption by
human FMO1 (diamonds), FMO2.1 (triangles) and FMO3 (squares) over an incubation time of 60
minutes.