Figure 9. Injury in a mouse model of fibrosis with 4 weeks CCl₄ and α-CD147 antibody intervention.

Cirrhosis was induced in a mouse model of liver injury (Balb/c) with CCl₄. An antibody targeting CD147 (RL73.2) was given twice weekly for 4 weeks, mice given an equal amount of IgG were used as control. There was no appreciable phenotype with either α-CD147 antibody or IgG control treatment in the absence of CCl₄ (not shown). The injury groups are CCl₄ (+/− isotype control) and CCl₄ with antibody targeting CD147. Quantitative data of PSR staining is shown in panel A. Injury as assessed by AST (Panel B), α-SMA (Panel C), Collagen I (Panel D), TGF-β (Panel E) and Collagen IV (Panel F) were all significantly reduced in CCl₄ injury with α-CD147 antibody intervention compared to the IgG control treated with CCl₄. All groups are n = 4−6 with data expressed as mean and SEM. *p<0.05.