Figure 2. α-synuclein fibril core regions as determined by ssNMR studies. Upper panel: schematic representation of the α-synuclein segment from residue 1 to 100 involved in structural changes. Lower panel: proposed β-strand (indicated as red pentagons) organization of different human (Hu) α-synuclein fibrillar assemblies determined by different groups: (A) reference 68 (B) reference 67 (C) reference 69 (D) reference 70 (E) reference 71 (F) reference 65.