Table 2.

Significantly remodeled genes in the right ventricle of failing human heart: TaqMan gene expression analysis

Gene	Significant Genes (FDR 10.89%)
	Encoded protein	Score (d)	Fold change
SCN1A	Neural/muscle Na+ channel	−2.80	0.17
KCNK3	TASK two-pore K+ channel	−2.53	0.12
CNN1	Calponin 1	−2.24	0.20
KCNJ12	Kir2.2 (potential IK1 contributor)	−2.24	0.43
HCN4	Hyperpolarization-activated K+ channel	−2.22	0.33
TBX2	T-box transcription factor	−1.96	0.58
ADRB3	β3-Adrenoreceptor	−1.83	0.09
ATP1B1	Na+-K+-ATPase β1-subunit	−1.82	0.58
KCNK6	TWIK2 two-pore K+ channel	−1.79	0.39
PANX1	Pannexin 1	−1.70	0.42
GJC1	Cx45	−1.63	0.48
ATP2B4	Sarcolemmal Ca2+-ATPase	−1.62	0.69
ITPR3	Inositol 1,4,5-triphosphate receptor 3	−1.57	0.41
TBX3	T-box transcription factor	−1.55	0.38
KCNH2	Kv11.1 (IKr)	−1.52	0.54
ADRB2	β2-Adrenoreceptor	−1.49	0.58
PPP3CA	Protein phosphatase 3	−1.49	0.54

The protein encoded by the identified genes are indicated, along with the Significant Analysis Microarrays d score and fold expression change for each target.

FDR, false discovery rate; Kir2.2, inward rectifying potassium channel; I_K1, inward rectifying background potassium current; Cx, connexin; I_Kr, rapidly activating delayed-rectifier potassium current..