Table 2.
GO terms enriched with commonly upregulated genes (n = 87) in rat mammary gland 49 days after either pregnancy or hormone treatment
| P |
H |
||||||
|---|---|---|---|---|---|---|---|
| GO Term | % | P Value | Affy ID | Gene Symbol | Gene Name | Log FC | Log FC |
| Extracellular region | 20.8 | 3.8E-4 | 1388605_at | Wfdc3 | WAP four-disulfide core domain 3 (predicted) | 3.02 | 1.49 |
| 1368924_at | Ghr | growth hormone receptor | 0.52 | 0.56 | |||
| 1387748_at | Lep | leptin | 1.06 | 0.72 | |||
| 1379677_at | Tnfsf13 | tumor necrosis factor (ligand) superfamily, member 13 | 0.56 | 0.5 | |||
| 1371099_at | polymeric immunoglobulin receptor | 3.14 | 2.21 | ||||
| 1387735_at | Mmp8 | matrix metallopeptidase 8 | 1.56 | 0.84 | |||
| 1392172_at | Ccl9 | chemokine (C-C motif) ligand 9 | 1.53 | 0.6 | |||
| 1369539_at | St3 gal3 | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 | 0.64 | 0.49 | |||
| 1368913_at | Csn2 | casein beta | 2.96 | 2.36 | |||
| 1368657_at | Mmp3 | matrix metallopeptidase 3 | 1.16 | 0.73 | |||
| 1387751_at | Wap | whey acidic protein | 2.12 | 1.25 | |||
| 1391323_at | Tf | signal recognition particle receptor, B subunit; transferrin | 1.07 | 0.66 | |||
| 1368008_at | Prom1 | prominin 1 | 0.71 | 0.72 | |||
| 1371130_at | Slc1a3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.49 | 0.58 | |||
| Peptidase M10A, matrix metallopeptidase | 4.2 | 1.4E-3 | 1387735_at | Mmp8 | matrix metallopeptidase 8 | 1.56 | 0.84 |
| 1368657_at | Mmp3 | matrix metallopeptidase 3 | 1.16 | 0.73 | |||
| 1368530_at | Mmp12 | matrix metallopeptidase 12 | 2.22 | 1.56 | |||
| Response to organic substance | 13.9 | 5.5E-3 | 1367660_at | Fabp3 | fatty acid binding protein 3 | 3.04 | 2.09 |
| 1394028_at | Dusp10 | dual specificity phosphatase 10 (predicted) | 0.75 | 0.74 | |||
| 1368924_at | Ghr | growth hormone receptor | 0.52 | 0.56 | |||
| 1387748_at | Lep | leptin | 1.06 | 0.72 | |||
| 1369337_at | Adcy10 | adenylate cyclase 10 (soluble) | 0.85 | 0.52 | |||
| 1369658_at | Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | 1.14 | 0.65 | |||
| 1368657_at | Mmp3 | matrix metallopeptidase 3 | 1.16 | 0.73 | |||
| 1391323_at | Tf | signal recognition particle receptor, B subunit; transferrin | 1.07 | 0.66 | |||
| 1382692_at | RGD15 | similar to Clecsf12 protein (predicted) | 1.15 | 0.63 | |||
| 65140 | |||||||
| 1370026_at | Cryab | crystallin, alpha B | 0.54 | 0.71 | |||
| Plasma membrane part | 18.1 | 6.8E-3 | 1388240_a_at | Itga7 | integrin alpha 7 | 0.64 | 0.52 |
| 1368317_at | Aqp7 | aquaporin 7 | 0.55 | 0.54 | |||
| 1371130_at | Slc1a3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.49 | 0.58 | |||
| 1368924_at | Ghr | growth hormone receptor | 0.52 | 0.56 | |||
| 1368187_at | Gpnmb | glycoprotein (transmembrane) nmb | 1.32 | 0.87 | |||
| 1369337_at | Adcy10 | adenylate cyclase 10 (soluble) | 0.85 | 0.52 | |||
| 1379677_at | Tnfsf13 | tumor necrosis factor (ligand) superfamily, member 13 | 0.56 | 0.5 | |||
| 1382692_at | RGD15 | similar to Clecsf12 protein (predicted) | 1.15 | 0.63 | |||
| 65140 | |||||||
| 1370614_s_at | Stk39 | serine/threonine kinase 39, STE20/SPS1 homolog (yeast) | 0.65 | 0.5 | |||
| 1375756_at | RGD13 | similar to ionized calcium binding adapter molecule 2 (Iba2) (predicted) | 0.54 | 0.51 | |||
| 05081 | |||||||
| 1391323_at | Tf | signal recognition particle receptor, B subunit; transferrin | 1.07 | 0.66 | |||
| 1368008_at | Prom1 | prominin 1 | 0.71 | 0.72 | |||
| 1387889_at | Folr1 | folate receptor 1 (adult) | 1.14 | 1.03 | |||
| Signal | 20.8 | 8.9E-3 | 1388240_a_at | Itga7 | integrin alpha 7 | 0.64 | 0.52 |
| 1371099_at | polymeric immunoglobulin receptor | 3.14 | 2.21 | ||||
| 1368924_at | Ghr | growth hormone receptor | 0.52 | 0.56 | |||
| 1368187_at | Gpnmb | glycoprotein (transmembrane) nmb | 1.32 | 0.87 | |||
| 1387748_at | Lep | leptin | 1.06 | 0.72 | |||
| 1398241_a_at | Spt1 | salivary protein 1 | 1.76 | 2.16 | |||
| 1374933_at | Mcam | melanoma cell adhesion molecule | 0.49 | 0.54 | |||
| 1369468_at | Fzd4 | frizzled homolog 4 (Drosophila) | 0.62 | 0.54 | |||
| 1387735_at | Mmp8 | matrix metallopeptidase 8 | 1.56 | 0.84 | |||
| 1368913_at | Csn2 | casein beta | 2.96 | 2.36 | |||
| 1396947_at | Lgr4 | leucine-rich repeat-containing G protein-coupled receptor 4 | 0.57 | 0.51 | |||
| 1368657_at | Mmp3 | matrix metallopeptidase 3 | 1.16 | 0.73 | |||
| 1387751_at | Wap | whey acidic protein | 2.12 | 1.25 | |||
| 1391323_at | Tf | signal recognition particle receptor, B subunit; transferrin | 1.07 | 0.66 | |||
| 1368530_at | Mmp12 | matrix metallopeptidase 12 | 2.22 | 1.56 |
GO, Gene Ontology; P, full-term pregnancy; H, 21 days of exogenous hormone treatment; FC, fold change.