Fig. 11.

Effect of hepatic SIRT1 function on high-fat diet (HFD)-induced weight gain and glucose homeostasis. WT (Sirt1^F/F) and liver-specific Sirt1 mutant (Sirt1^ΔLiv) mice were fed a 60% HFD for 14 wk. A and B: body mass (A) and %weight gain (B) were measured weekly for Sirt1^F/F and Sirt1^ΔLiv mice on HFD. C: body composition was quantified using EchoMRI at the end of the study. D and E: glucose (IPGTT; D) and insulin tolerance tests (ITT; E) after 14 wk on HFD. Significant differences between Sirt1^F/F and Sirt1^ΔLiv mice are indicated (*P < 0.05).