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Expression of PPARα target and SIRT1-associated genes after fasting. Sirt1F/F and Sirt1ΔLiv mice were fed 60% HFD for 14 wk and then switched to WY diet or HFD for 5 days. RT-qPCR analysis was performed on liver samples, and values were normalized to β-actin and expressed as fold change from Sirt1F/F mice. Significant differences between HFD or HFD with WY treatment are indicated (*P < 0.05). Significant differences between Sirt1F/F and Sirt1ΔLiv mice are indicated (†P < 0.05).
