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Aged Sirt1ΔLiv mice have similar physiological responses to WY as young mice. Nine-month-old Sirt1F/F and Sirt1ΔLiv mice were treated with WY for 5 days. A: liver/body mass ratio and serum cholesterol, triglyceride, and NEFA levels. B: hepatic concentrations of triglycerides, cholesterol, and NEFA. Significant differences between control and WY-14643 treatment are indicated (*P < 0.05). Significant differences between Sirt1F/F and Sirt1ΔLiv mice are indicated (†P < 0.05).
