Fig. 9.
Deacetylase activity of SIRT1 has minor influence on physiological response to fasting. WT (Sirt1F/F) and liver-specific Sirt1 mutant (Sirt1ΔLiv) mice were fasted for 24 h. A: liver/body mass ratio was measured as well as serum triglyceride, cholesterol, and NEFA concentrations. B: hepatic concentrations of total triglycerides, cholesterol, and NEFA. Significant differences between fed and fasted mice are indicated (*P < 0.05). Significant differences between Sirt1F/F and Sirt1ΔLiv mice are indicated (†P < 0.05).