Table 3.
Menstrual and hormonal changes
| Variable | Average Pre | Average Post | Mean %Change | P Value |
|---|---|---|---|---|
| Menstrual cycle length, days | 28.9 ± 2.0 | 29.4 ± 1.7 | +3.6 ± 0.01 | 0.51 |
| Luteal phase length, days | 11.3 ± 2.5 | 11.1 ± 2.4 | +1.4 ± 0.25 | 0.83 |
| Luteal phase deficiency | ||||
| %Cycles, out of 14 cycles) | 21% | 21% | 0.0 | 1.00 |
| No. of subjects (out of 7) | 3 | 3 | 0.0 | |
| Estrogen AUC, E1G ng/ml | ||||
| Total cycle | 11,20.1 ± 309.1 | 908.2 ± 160.5 | −18.9 ± 15.2 | 0.03 |
| Follicular phase | 672.9 ± 181.3 | 610.3 ± 139.8 | −6.8 ± 16.9 | 0.20 |
| Luteal phase | 452.0 ± 174.9 | 291.5 ± 63.8 | −30.3 ± 19.0 | 0.02 |
| Progesterone AUC, PdG, ng/ml | ||||
| Total cycle | 88.2 ± 35.9 | 67.3 ± 20.4 | −23.7 ± 28.9 | 0.05 |
| Follicular phase | 20.6 ± 10.5 | 19.7 ± 4.1 | −21.6 ± 66.6 | 0.85 |
| Luteal phase | 67.7 ± 32.5 | 47.4 ± 19.9 | −25.7 ± 17.7 | 0.002 |
Values are means ± SD; n = 7 subjects. Pre, cycles 1 and 2; Post, cycles 6 and 7; AUC, area under the curve; E1G, estrone-1-glucuronide; PdG, pregnanediol-3-glucuronide.