Table 2.
Top 15 genes differentially regulated for each of the three comparisons
| Genes up-regulated in OB/LN category | Genes down-regulated in OB/LN category | ||||||
|---|---|---|---|---|---|---|---|
| Symbol | Gene name | FC | P | Symbol | Gene name | FC | P |
| HBM | hemoglobin, mu | 7.41 | 0.001 | CXCL12 | chemokine (C-X-C motif) ligand 12 | −3.01 | 0.038 |
| ALAS2 | aminolevulinate, delta-, synthase 2 | 5.87 | 0.007 | SERPINF1 | serpin peptidase inhibitor, clade F, member 1 | −2.95 | 0.029 |
| S100A8 | S100 calcium binding protein A8 | 5.41 | 0.012 | ROR2 | receptor tyrosine kinase-like orphan receptor 2 | −2.80 | 0.019 |
| HBG1 | hemoglobin, gamma A | 4.64 | 0.013 | IL13RA2 | interleukin 13 receptor, alpha 2 | −2.61 | 0.027 |
| CA1 | carbonic anhydrase I | 4.12 | 0.003 | NID2 | nidogen 2 (osteonidogen) | −2.59 | 0.001 |
| HBG2 | hemoglobin, gamma G | 4.03 | 0.008 | MFAP2 | microfibrillar-associated protein 2 | −2.49 | 0.012 |
| S100A9 | S100 calcium binding protein A9 | 3.95 | 0.008 | C1QTNF6 | C1q and tumor necrosis factor related protein 6 | −2.49 | 0.012 |
| KAL1 | Kallmann syndrome 1 sequence | 3.55 | 0.014 | RCAN2 | regulator of calcineurin 2 | −2.29 | 0.014 |
| NFE2 | nuclear factor (erythroid-derived 2), 45kDa | 3.52 | 0.016 | LHX2 | LIM homeobox 2 | −2.29 | 0.011 |
| LTB | lymphotoxin beta | 3.46 | 0.004 | CPXM1 | carboxypeptidase X (M14 family), member 1 | −2.17 | 0.045 |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 3.41 | 0.010 | CTHRC1 | collagen triple helix repeat containing 1 | −2.13 | 0.043 |
| AQP9 | aquaporin 9 | 3.33 | 0.009 | LOC645166 | lymphocyte-specific protein 1 pseudogene | −2.12 | 0.018 |
| MT1H | metallothionein 1H | 3.20 | 0.039 | C21orf100 | C21 open reading frame 100 | −2.10 | 0.001 |
| CCND2 | cyclin D2 | 3.10 | 0.011 | MAGED4B | melanoma antigen family D, 4B; melanoma antigen family D, 4 | −2.01 | 0.005 |
| HBD | hemoglobin, delta | 3.09 | 0.021 | ADAMTSL1 | ADAMTS-like 1 | −2.00 | 0.005 |
| Genes up-regulated in OB/OW category | Genes down-regulated in OB/OW category | ||||||
| HBM | hemoglobin, mu | 6.65 | 0.008 | SERPINF1 | serpin peptidase inhibitor, clade F, member 1 | −3.99 | 0.009 |
| ALAS2 | aminolevulinate, delta-, synthase 2 | 5.73 | 0.010 | CXCL12 | chemokine (C-X-C motif) ligand 12 | −3.42 | 0.024 |
| HBG1 | hemoglobin, gamma A | 5.07 | 0.006 | IL13RA2 | interleukin 13 receptor, alpha 2 | −3.35 | 0.009 |
| MT1H | metallothionein 1H | 4.66 | 0.009 | FABP5L2 | fatty acid binding protein 5-like 2 | −3.25 | 0.011 |
| S100A8 | S100 calcium binding protein A8 | 4.65 | 0.013 | ROR2 | receptor tyrosine kinase-like orphan receptor 2 | −3.21 | 0.010 |
| PAMR1 | peptidase domain containing associated with muscle regeneration 1 | 4.11 | 0.002 | CPXM1 | carboxypeptidase X (M14 family), member 1 | −3.04 | 0.009 |
| NFE2 | nuclear factor (erythroid-derived 2) | 4.07 | 0.003 | AGTR1 | angiotensin II receptor, type 1 | −2.90 | 0.017 |
| HBG2 | hemoglobin, gamma G | 4.03 | 0.010 | NCAM2 | neural cell adhesion molecule 2 | −2.77 | 0.005 |
| CD247 | CD247 molecule | 3.97 | 0.008 | LOC401233 | similar to HIV TAT specific factor 1 | −2.55 | 0.017 |
| CILP | cartilage intermediate layer protein | 3.93 | 0.002 | RCAN2 | regulator of calcineurin 2 | −2.54 | 0.008 |
| F5 | coagulation factor V | 3.66 | 0.016 | CTHRC1 | collagen triple helix repeat containing 1 | −2.50 | 0.019 |
| CSF3R | colony stimulating factor 3 receptor | 3.61 | 0.015 | NID2 | nidogen 2 (osteonidogen) | −2.47 | 0.001 |
| MMP21 | matrix metallopeptidase 21 | 3.52 | 0.006 | C1QTNF6 | C1q and tumor necrosis factor related protein 6 | −2.42 | 0.014 |
| EPB42 | erythrocyte membrane protein band 4.2 | 3.50 | 0.015 | C21orf34 | chromosome 21 open reading frame 34 | −2.37 | 0.007 |
| KAL1 | Kallmann syndrome 1 sequence | 3.47 | 0.012 | PHLDB2 | pleckstrin homology-like domain, family B, member 2 | −2.35 | 0.018 |
| Genes up-regulated in OW/LN category | Genes down-regulated in OW/LN category | ||||||
| IKZF3 | IKAROS family zinc finger 3 (Aiolos) | 2.64 | 0.001 | MMP21 | matrix metallopeptidase 21 | −2.95 | 0.028 |
| NTNG1 | netrin G1 | 2.06 | 0.013 | SLN | sarcolipin | −2.69 | 0.007 |
| C21orf34 | chromosome 21 open reading frame 34 | 1.89 | 0.027 | ZMYND11 | zinc finger, MYND domain containing 11 | −1.99 | 0.014 |
| RXRG | retinoid X receptor, gamma | 1.83 | 0.003 | HMGCLL1 | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 | −1.95 | 0.003 |
| PRAMEF18 | PRAME family member 18; PRAME family member 3 | 1.82 | 0.007 | MYADM | myeloid-associated differentiation marker | −1.90 | 0.007 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 1.78 | 0.023 | TNNT3 | troponin T type 3 (skeletal, fast) | −1.87 | 0.045 |
| PCDHA12 | protocadherin alpha 12 | 1.74 | 0.039 | GALNTL2 | N-acetylgalactosaminyltransferase-like 2 | −1.86 | 0.020 |
| RIOK3 | RIO kinase 3 (yeast) | 1.70 | 0.014 | BDKRB1 | bradykinin receptor B1 | −1.84 | 0.012 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 1.69 | 0.019 | PTHLH | parathyroid hormone-like hormone | −1.79 | 0.002 |
| ANGPT1 | angiopoietin 1 | 1.68 | 0.011 | SALL1 | sal-like 1 (Drosophila) | −1.77 | 0.045 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 1.68 | 0.019 | PIPOX | pipecolic acid oxidase | −1.76 | 0.005 |
| SULT2B1 | sulfotransferase family, cytosolic, 2B, member 1 | 1.68 | 0.039 | BRDT | bromodomain, testis-specific; hCG1811337 | −1.71 | 0.028 |
| NR3C2 | nuclear receptor subfamily 3, group C, member 2 | 1.66 | 0.011 | MICALCL | MICAL C-terminal like | −1.70 | 0.020 |
| HERC5 | hect domain and RLD 5 | 1.66 | 0.019 | FOXR2 | forkhead box R2 | −1.69 | 0.002 |
| CT45A5 | cancer/testis antigen family 45, member A5 | 1.65 | 0.012 | GABRG1 | gamma-aminobutyric acid (GABA) A receptor, gamma 1 | −1.67 | 0.016 |
LN = lean; OW = overweight; OB = obese; FC = fold change