Table 5.
Functional classifications of genes differentially expressed by BMI
| Biological processes | BMI category | E score | P value | Genes in the process | ||
|---|---|---|---|---|---|---|
| LN | OW | OB | ||||
| Oxygen transport | ↓ | - | ↑ | 4.51 | <0.001 | HBG1, HBG2, HBM, HBQ1, HBD |
| Oxygen carrier | ↓ | - | ↑ | 3.78 | <0.001 | HBG1, HBG2, HBQ1, HBD |
| Calcium binding region | ↓ | - | ↑ | ↓2.97 | <0.001 | S100P, S100A12, S100A8, S100A9 |
| Chelation | ↓ | - | ↑ | 2.52 | 0.001 | MT1F, MT1X, MT1H |
| T cytotoxic cell pathway | ↓ | - | ↑ | 1.81 | 0.013 | CD247, CD3D, CD2 |
| Platelet alpha granule lumen | ↓ | - | ↑ | 1.80 | 0.006 | F5, PPBP, CLU, THBS1 |
| Negative regulation of apoptosis | ↓ | - | ↑ | 1.45 | 0.034 | IL1B, FOXO1, SNCA, STRADB, CLU, BTC, THBS1, PROK2 |
| Mitogen | ↓ | - | ↑ | 1.35 | 0.033 | IL1B, PPBP, BTC |
| Leukocyte chemotaxis | ↓ | - | ↑ | 1.27 | 0.041 | IL1B, CCL5, S100A9 |
| Cellular ion homeostasis | ↓ | - | ↑ | 1.22 | 0.044 | TMPRSS3, CCL5, IL1B, MT1H, ALAS2, SNCA, MAL, PROK2 |
| Extracellular matrix | ↑ | - | ↓ | 2.90 | <0.001 | MMP28, CTHRC1, ZP4, LAMB1, NID2, MFAP2, ADAMTSL1 |
| Glioma | ↑ | - | ↓ | 1.43 | 0.020 | CALML6, HRAS, CAMK2D |
| Metal ion binding* | ↑ | - | ↓ | 1.33 | 0.041 | ZFP64, ADA, CPXM1, CA5A, EHD1, NID2, UBR7, RCN1, ZBTB8A, PDZRN3 |
| Immunoglobulin I-set | ↑ | - | ↓ | 0.89 | 0.021 | CADM4, ROR2, ADAMTSL1, IGDCC4 |
| Region of interest:Alpha | - | ↓ | ↑ | 6.57 | <0.001 | MT1E, MT1F, MT1H, MT2A, MT1A, MT1M |
| Oxygen transport | - | ↓ | ↑ | 4.33 | <0.001 | HBG1, HBG2, HBM, HBQ1, HBD |
| Oxygen carrier | - | ↓ | ↑ | 3.62 | <0.001 | HBG1, HBG2, HBQ1, HBD |
| Calcium-binding region | - | ↓ | ↑ | 2.39 | 0.002 | S100P, S100A12, S100A8, S100A9 |
| DNA-binding region | - | ↓ | ↑ | 2.28 | 0.005 | FOXR2, FOXO1, FOXD1, FOXP4, FOXC2 |
| Heme | - | ↓ | ↑ | 2.04 | 0.007 | HBG1, HBG2, HBM, HBQ1 |
| Domain:SEC7 | - | ↓ | ↑ | 1.64 | 0.020 | IQSEC1, PSD3, KIAA1244 |
| T cytotoxic cell pathway | - | ↓ | ↑ | 1.50 | 0.028 | CD247, CD3D, CD2 |
| Domain:C-type lectin | - | ↓ | ↑ | 1.47 | 0.024 | FCER2, KLRB1, KLRC3, CD69, SELL |
| Regulation of apoptosis* | - | ↓ | ↑ | 1.38 | 0.039 | SNCA, RARB, PLAGL1, GLI3, PROK2, FOXC2, SORT1, SEMA4D, SOS1, THBS1 |
| Hemopexin-like 2 | - | ↓ | ↑ | 1.36 | 0.040 | PRG4, MMP21, MMP25 |
| Cellular ion homeostasis | - | ↓ | ↑ | 1.34 | 0.029 | SNCA, ATP2A2, PROK2, MT1H, ITPR3, MT2A, IL1B, CCL5, ALAS2, EGR2, PRKCZ, MAL |
| Negative regulation of apoptosis | - | ↓ | ↑ | 1.31 | 0.046 | SORT1, IL1B, FOXO1, SEMA4D, SNCA, STRADB, CLU, PRKCZ, THBS1, FOXC2, PROK2 |
| Metal ion binding* | - | ↓ | ↑ | 1.29 | 0.041 | S100A8, S100A9, SNCA, MAP3K8, RARB, RREB1, F5, ADAMTS1, ADAMTS5, ENPP3 |
| Platelet alpha granule lumen | - | ↓ | ↑ | 1.23 | 0.024 | F5, PPBP, CLU, THBS1 |
| Region of interest:Spacer | - | ↓ | ↑ | 1.09 | 0.040 | ADAMTS13, ADAMTS1, ADAMTS5 |
| Glucosamine metabolic process | - | ↑ | ↓ | 1.99 | 0.009 | LARGE, AMDHD2, GNPDA1 |
| Cell morphogenesis involved in differentiation | - | ↑ | ↓ | 1.32 | 0.031 | NCAM2, FEZ1, NTNG1, LAMB1, LHX2, CXCL12 |
| Regulation of leukocyte migration | - | ↑ | ↓ | 1.24 | 0.009 | ADA, F7, CXCL12 |
| Axon guidance | ↑ | ↓ | - | 0.84 | 0.031 | SEMA3B, PVRL1, NTN1 |
BMI = body mass index, LN = lean, OW = overweight, OB = obese; E = enrichment;
*
only 10 genes listed