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Structure and pharmacological profile of (S)-16, ML381 (VU0480131). A) Structure and pharmacology of ML381. B) [3H]NMS competition binding [n = 3] in membranes prepared from human M5 cells, showing competitive displacement (Ki = 340 nM). C) CRCs of ML381 for human M5 (hM5 IC50 = 450 nM) and human M1-M4 (hM1-M4 IC50s >30 μM). D) CRCs of ML381 for rat M5 (rM5 IC50 = 1.65 μM) and rat M1-M4 (rM1-M4 IC50s >30 μM).
