Skip to main content
. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: ChemMedChem. 2014 Apr 1;9(8):1677–1682. doi: 10.1002/cmdc.201402051

Scheme 3.

Scheme 3

Preparation of (S)-16 and (R)-16, single enantiomers of racemic 7. Reagents and conditions: a) NosCl, DIEPA, CH2Cl2, rt, 78–90% b) MeOH, PPh3, DIAD, CH2Cl2, rt, 74–90% c) 3-ClPhSH, K2CO3, MeCN, rt, 20% d) 8, HATU, DIEPA, CH2Cl2, rt, 89–96%. Enantiopurity >99% ee as analysed by chiral SFC.