Skip to main content
. Author manuscript; available in PMC: 2015 Jul 28.
Published in final edited form as: Angew Chem Int Ed Engl. 2014 Apr 6;53(31):8037–8040. doi: 10.1002/anie.201400870

Figure 1.

Figure 1

Influence of ligand spacing and valency on inhibitory potency of polypeptide inhibitors. (A) Influence of ligand spacing on the inhibitory potency of polypeptide inhibitors of the form (H)10-SE[LIG(SE)m]2. Estimates of the corresponding RMS linker lengths can be found in Table 2. (B) Influence of valency on the inhibitory potency of polypeptide inhibitors of the form (H)10-SE[LIG(SE)5]n. (C) SEC elution profile of (H)10-SE[LIG(SE)5]7 polypeptide inhibitors. (D) Comparison of dose response curves for (H)10-SE[LIG(SE)5]7 (line with filled circles), Ac-HTSTYWWLDGAPK-Am inhibitory peptide (line with open triangles), and negative control (H)10-SE[CTRL(SE)5]7 polypeptide (line with open circles).