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. Author manuscript; available in PMC: 2015 Jul 28.
Published in final edited form as: Angew Chem Int Ed Engl. 2014 Apr 6;53(31):8037–8040. doi: 10.1002/anie.201400870

Scheme 1. Controlling the activity of polyvalent molecules.

Scheme 1

(A) Cartoon showing the key parameters that influence the efficacy of polyvalent molecules – valency and spacing. The valency of the polyvalent molecule depicted in the figure is 4. (B) Cartoon showing a representative image of (H)10-SE[LIG-(SE)5]4 polypeptide. Color scheme: black, 12-mer peptide ligand (HTSTYWWLDGAP); blue, decahistidine tag; red, serine; green, glutamic acid.