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. Author manuscript; available in PMC: 2015 Jul 28.
Published in final edited form as: Angew Chem Int Ed Engl. 2014 Apr 6;53(31):8037–8040. doi: 10.1002/anie.201400870

Scheme 2. Cartoon representing the binding of the polypeptide-based inhibitors to adjacent sites on (PA63)7.

Scheme 2

(A) Structure of (PA63)7 with black dots on individual PA63 monomers representing the predicted binding sites (P184, L187, K197, and R200) for the 12-mer ligand (B) Cartoon showing the interaction of the 6-mer “TYWWLD” (white triangle) with its binding site on PA63 (black sector symbol). (C) Cartoon representing interactions between a divalent polypeptide and binding sites on adjacent PA63 monomers of (PA63)7.