Table 1. Urine and plasma cell-free DNA BRAF VGOOE mutations.

Patient#	Age at diagnosis	Gender	Involvement	Urine BRAF VGOOE/WT	Plasma BRAF VGOOE/WT	Patient Tissue BRAFstatus
1	59	Male	CNS, cardiac, bones, renal	V600E (22.590%)	V600E (8.598%)	V600E
2*	43	Male	CNS, bones, renal	V600E (0.311%)	V600E (1.522%)	V600E
3	26	Male	Skin	Wild-type (0.010%)	Wild-type (0.063%)	Wild-type
4	71	Female	Bones, lymph nodes	V600E (0.159%)	Wild-type (0.047%)	Unknown**
5	43	Female	CNS, bones	V600E (4.940%)	V600E (0.261%)	Unknown**
6	49	Male	CNS, cardiac, omentum, retroperitoneum	Wild-type indeterminate (0.079%)	Wild-type (0.048%)	Unknown**

CNS; central nervous system

^*Urine and plasma collected on different dates

^**lnsuficient tissue for molecular analysis